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The radiation modifying properties of carnosine
Authors:S E Severin  A A Boldyrev  S L Stvolinski?  M M Bordiukov  E N Goncharenko  L I Deev  I E Malinina  Iu B Kudriashov
Abstract:The influence of carnosine (beta-alanyl-l-histidine) on the survival rate of albino mice subjected to whole-body X-irradiation has been investigated. Carnosine (50-200 mg/kg/day) administered per os during a period of 20 days before irradiation (5.0 Gy) increased the survival rate by 45-65%, whereas the administration of carnosine within 30 days after irradiation (5.5 Gy) produced an insignificant protective effect and caused inhibition of the postirradiation histamine accumulation in the spleen.
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