Peptides derived from repulsive guidance molecule act as antagonists |
| |
Authors: | Suda Masayoshi Hata Katsuhiko Sawada Aika Nakamura Yuka Kubo Takekazu Yamaguchi Atsushi Yamashita Toshihide |
| |
Affiliation: | a Department of Neurobiology, Graduate School of Medicine, Chiba University, Japan b Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan |
| |
Abstract: | Repulsive guidance molecule (RGM) is a membrane-bound protein that was originally identified as an axon guidance molecule in the visual system [T. Yamashita, B.K. Mueller, K. Hata, Neogenin and RGM signaling in the central nervous system, Curr. Opin. Neurobiol. 17 (2007) 29-34]. Functional studies in Xenopus and chick embryos have revealed the roles of RGM in axon guidance and laminar patterning, while those in mouse embryos have demonstrated its function in regulating the cephalic neural tube closure. Importantly, RGM inhibition enhanced the growth of injured axons and promoted functional recovery after spinal cord injury in rats. Here, we identified two RGMa-derived peptides that functioned as antagonists against RGMa. The peptides studied in vitro dose-dependently suppressed the neurite growth inhibition and growth cone collapse induced by RGMa. Thus, these peptides are promising reagents to treat injuries of the central nervous system. |
| |
Keywords: | Axon growth Neurite Inhibitor Repulsive guidance molecule |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|