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Serum gp70 production regulated by a gene on murine chromosome 7 |
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| Authors: | Naoki Maruyama Cary O Lindstrom Hidetoshi Sato Frank J Dixon |
| Institution: | (1) Department of Immunology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037 La Jolla, California;(2) Department of Pathology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113, Japan;(3) Present address: Department of Pathology, Chiba-Rosai Hospital, 2-16 Tatsumidai-Higashi, Ichihara, Chiba 290, Japan |
| Abstract: | We mated 129 mice (prototype strain of GIX + with C5713L/6 mice (prototype strain of GIX –) and thereby identified the gene controlling enhancement of serum gp70 production after lipopolysaccharide (LPS) injection. This gene has been tentatively designated Sgp-2. Sgp-2 is linked with the Hbb locus on chromosome 7. The estimated frequency of recombination between Sgp-2 and Hbb in this setting is about 20%. |
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