Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides |
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| Authors: | Mitsch Andreas Wissner Pia Silber Katrin Haebel Peter Sattler Isabel Klebe Gerhard Schlitzer Martin |
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| Affiliation: | Institut für Pharmazeutische Chemie, Philipps-Universit?t Marburg, Marbacher Weg 6, D-35032 Marburg, Germany. |
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| Abstract: | We have designed arylfurylacryl-substituted benzophenones as non-thiol farnesyltransferase inhibitors utilizing a novel aryl binding site of farnesyltransferase. These compounds display activity in the low nanomolar range. |
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