ADAM 10: an active metalloprotease expressed during avian epithelial morphogenesis |
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Authors: | Hall Ronelle J Erickson Carol A |
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Affiliation: | Section of Molecular and Cellular Biology, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA. rjyoung@ucdavis.edu |
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Abstract: | The ADAMs are a family of proteins containing multiple functional domains. We have cloned the avian orthologue of ADAM 10 and demonstrate that it has metalloprotease activity. Chick ADAM 10 is expressed in the developing dermatome and myotome of the somite, epidermis, gut endoderm, the epithelial tissues of the kidney, liver, and heart, and in neural crest cells. The expression patterns and protein distribution of ADAM 10 suggest it may play a significant role in the morphogenesis of several epithelial tissues. When a dominant-negative metalloprotease-mutant form of ADAM 10 is expressed in the ectoderm or ADAM 10 expression is knocked down with morpholinos, morphogenesis and tissue specification are altered. |
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Keywords: | Morphogenesis ADAM 10 Metalloprotease Epithelial-to-mesenchymal transformation Epithelium Ectoderm Somite Neural crest Heart Chicken embryo Morpholino |
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