Influence of the bystander phenomenon on the chromosome aberration pattern in human lymphocytes induced by in vitro α-particle exposure |
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Authors: | Ernst Schmid H Roos |
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Institution: | 1.Radiobiological Institute,University of Munich,Munich,Germany |
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Abstract: | A recent publication on both chromosome-type and chromatid-type aberrations in lymphocytes of patients during treatment with
radium-224 for ankylosing spondilitis has revived the question of whether the chromatid-type aberrations may be the consequence
of factors released by irradiated cells. Therefore, the aim of the present study was to investigate the influence of such
a bystander phenomenon on the chromosome aberration pattern of lymphocytes. Monolayers of human lymphocytes were irradiated
with 1 Gy of α-particles from an americium-241 source in the absence or presence of whole blood, autologous plasma or culture
medium. In the presence of any liquid covering the monolayer during irradiation, the chromatid-type aberrations were, contrary
to expectation, elevated. Whereas the intercellular distribution of dicentrics was significantly overdispersed, the chromatid-type
aberrations showed a regular dispersion. It can be concluded that the enhanced frequency of chromatid aberrations is the result
of a damage signal or a bystander phenomenon released by irradiated cells. |
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