Effects of carcinogenic and non-carcinogenic chemicals on plasma esterases in BALB/c mice |
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Authors: | Richard L. Tyndall Neal K. Clapp Kowetha A. Davidson Shirley P. Colyer Carl A. Burtis |
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Affiliation: | 1. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tenn. 37830 U.S.A.;1. Oak Ridge Associated Universities, Oak Ridge, Tenn. 37830 U.S.A.;7. Chemistry Division, Oak Ridge National Laboratory, Oak Ridge, Tenn. 37830 U.S.A. |
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Abstract: | Esterase profiles of plasma from female BALB/c mice treated with a variety of carcinogenic and weakly- or non-carcinogenic chemicals were analyzed. Mice treated with the potent carcinogens diethylnitrosamine, dinitrosopiperazine, dipropylnitrosamine, dimethylhydrazine, urethane, and dimethyldinitrosopiperazine had similarly altered plasma esterase profiles after 7 days' exposure to the chemicals. The alterations consisted of increased activity in 4 esterase bands. The increased activity persisted in some of the bands after cessation of carcinogen exposure. Exposure to high concentrations of the weakly- or non-carcinogenic compounds nitrosohydroxyproline, nitrosomethoxymethylamine, 1-nitroso-4 methylpiperazine, nitroso-2,6 dimethylpiperidine, and ethyl methanesulfonate caused no obvious plasma esterase alterations. Ingestion of carbon tetrachloride resulted in increased activity in one esterase band with concomitant decrease in a second band. Analysis of serum from test mice for levels of serum glutamic oxaloacetic transaminase, alkaline phosphatase, lactate dehydrogenase-lactate substrate, and D-gamma-glutamyl transpeptidase did not differentiate between mice treated with selected carcinogens and those treated with non-carcinogens and/or carbon tetrachloride. |
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Keywords: | ALP alkaline phosphatase AST serum glutamic oxaloacetic transaminase BHT butylated hydroxytoluene DEN diethylnitrosamine DNPZ dinitrosopiperazine DPN dipropylnitrosamine EMS ethyl methanesulfonate GGTP LD-L lactate dehydrogenase-lactate substrate NDMP nitroso-2,6 dimethylpiperidine NHP nitrosohydroxyproline NMMA nitrosomethoxymethylamine NMP 1-nitroso-4 methylpiperazine URTH urethane |
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