Microsomal metabolism of N-nitrosodi-n-propylamine: formation of products resulting from α-and β-oxidation |
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Authors: | Kwanghee K Park Michael C Archer |
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Institution: | Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Mass. 02139 U.S.A. |
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Abstract: | We have identified propionaldehyde, n-propanol, isopropanol and N-nitroso-2-hydroxy-propylpropylamine following incubation of N-nitrosodi-n-propylamine with a microsomal fraction from rat liver. Based on the yields of the various products, we have shown that β-oxidation occurs at about 15% of the level of α-oxidation. β-as well as α-oxidation was shown to be carried out by the microsomal mixed function oxidase system. N-nitroso-2-hydroxy-propylpropylamine is further oxidized by the microsomal preparation to yield N-nitroso-2-oxopropylpropylamine. |
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