Differential genotoxic effects of antitumor trans-[PtCl2(E-iminoether)2] and cisplatin in Escherichia coli |
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Authors: | Eva Janovsk Olga Novkov Giovanni Natile Viktor Brabec |
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Institution: | Eva Janovská, Olga Nováková, Giovanni Natile,Viktor Brabec, |
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Abstract: | In the present work, we measured survival and the platinum on the genome after treatment of repair-proficient or repair-deficient Escherichia coli strains with trans-PtCl2(E-iminoether)2] and compared these results with the effects of “classical” cisplatin. We found that toxicity of antitumor trans-PtCl2(E-iminoether)2] in repair-deficient trains was much less than that of cisplatin. This markedly reduced toxicity was not a consequence of the reduced uptake or low levels of DNA binding in the bacteria cells but rather appeared to reflect DNA binding mode of this trans-platinum drug different from that of cisplatin. |
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Keywords: | Cisplatin trans-Platinum drugs Antitumor Repair DNA |
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