Genetic control of two electrophoretic variants of glucosephosphate isomerase in the mouse (Mus musculus) |
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Authors: | Robert J DeLorenzo Frank H Ruddle |
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Institution: | (1) Department of Biology, Yale University, New Haven, Connecticut |
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Abstract: | The autosomal variation and the genetic control of GPI has been determined by a comparison of electrophoretic patterns of F1 and backcross progeny of three inbred strains of mice. The locus controlling the production of GPI in the mouse has been designated Gpi-1. Two alleles at this locus have been described and designated Gpi-1
a and Gpi-1
b, which represent, respectively, the slow and fast electrophoretic forms. Twenty-seven inbred strains of mice have been classified for these two alleles. The absence of close linkage of Gpi-1 to seven other genetic loci has been determined. It has been demonstrated that the polymorphism of Gpi-1 is widely distributed in feral mice. GPI was expressed in vitro and in four types of malignant tumors.Supported by U.S. Public Health Service Grants GM-09966, from General Medical Sciences, and GY 4193. |
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