急性心肌梗死患者肠道优势菌群分析

目的探讨急性心肌梗死患者肠道优势菌群的改变及其与疾病严重程度的关系。方法共筛选急性心肌梗死患者71名及正常健康体检者33名,急性心肌梗死患者根据是否心衰分为急性心肌梗死组36名和急性心肌梗死伴泵衰竭组35名,所有入选者收集大便及血清标本,分别采用qPCR及化学发光仪测定肠道优势菌群改变和血清脑钠肽前体及肌钙蛋白水平。结果急性心肌梗死患者肠道优势菌群显著改变,肠道肠杆菌以及肠球菌细菌数量较对照组显著增加,均与脑钠肽前体、肌钙蛋白、Killip分级显著正相关,而双歧杆菌、乳酸杆菌等细菌数量显著降低,与脑钠肽前体、肌钙蛋白、Killip分级显著负相关。结论急性心肌梗死患者呈现典型的肠道菌群紊乱,且与患者疾病严重程度相关。

Analysis of the intestinal predominant microbiota in acute myocardial infarction patients

Objective To explore the change of intestinal predominant microbiota in acute myocardial infarction patients and its relationship with disease severity. Methods 71 cases of acute myocardial infarction and 33 normal healthy controls were screened out. The acute myocardial infarction patients were divided into acute myocardial infarction group（ n = 36） and acute myocardial infarction with pump failure group（ n = 35） depending on whether having heart failure. The samples of serum and stool of all participants were detected by using qPCR and chemiluminescence respectively. Results The intestinal predominant microbiota significantly altered in patients with acute myocardial infarction; their Enterobacteriaceae and Enterococcus increased significantly compared with the control group,which was positively correlated with brain natriuretic peptide,troponin and Killip. The Bifidobacterium and Lactobacillus reduced significantly in the acute myocardial infarction group compared with the control group and negatively correlated with brain natriuretic peptide,troponin and Killip. Conclusion Typical intestinal microbiota disorder was detected in acute myocardial infarction patients and associated with the severity of disease.