围食膜: 害虫生物防治的潜在靶标

围食膜是昆虫中肠细胞分泌的一层特有的非细胞结构，由蛋白质、粘多糖和几丁质组成，是昆虫中肠细胞抵御随食物摄入的病原微生物入侵的第一道天然屏障。昆虫病毒增效蛋白、几丁质酶、荧光增白剂和外源凝集素等生物防治促进因子通过与围食膜上特异位点的结合，可破坏围食膜结构，改变其通透性，促进病原微生物对害虫的感染。该文综述了与昆虫围食膜密切相关的生防促进因子的增效活性及其作用机理，阐明了以围食膜为害虫生物防治靶标的应用前景。

Peritrophic membrane: a potential target for biocontrol of pest insects

Peritrophic membrane (PM), composed of proteins, glycosaminoglycans and chitins, is an acellular structure secreted by midgut cells and lines along digestive tract in most insects. It is the first barrier and plays an important role in protecting the gut epithelium from infection of pathogens. Biocontrol-promoting factors, such as baculovirus enhancin, chitinase, calcofluor and agglutinin, can destroy PM's structure, vary its permeability and facilitate infection of pathogens to pest insects by binding with PM components specifically. In the current paper, enhancing activity and mechanism of each biocontrol-promoting factor were summarized and opportunities for the development of new midgut targeting strategies for control of pest insects were prospected.