The nature of heme—aniline interactions during hemin-mediated oxygen activation and insertion reactions |
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| Authors: | Paul A. Adams Caroline Adams Mervyn C. Berman Michael C. Lawrence |
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| Affiliation: | M.R.C. Biomembrane Research Unit, Department of Chemical Pathology, University of Cape Town Medical School, Republic of South Africa |
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| Abstract: | The interaction of aniline with hemin during oxygen activation and insertion mediated by the metalloporphyrin has been studied by a combined theoretical, semiempirical, and experimental approach. Results indicate that association is via a planar π bonding interaction between the aromatic π electrons of the amine and tetrapyrrole ring system. The effect of very high concentrations of hydroxyl radical scavengers on the system is discussed. |
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