Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation |
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| Authors: | Ye-Ming Lee Wei-Fan Chen Duen-Suey Chou Thanasekaran Jayakumar Ssu-Yu Hou Jie-Jen Lee George Hsiao Joen-Rong Sheu |
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| Institution: | (1) Department of Surgery, Hsinchu Mackay Memorial Hospital, Hsinchu; Mackay Medicine, Nursing and Management College, Taipei, Taiwan;(2) Department of Pharmacology, Taipei Medical University, Taipei, Taiwan;(3) Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan |
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| Abstract: | Background 3-Hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been widely used to reduce cardiovascular
risk. These statins (i.e., simvastatin) may exert other effects besides from their cholesterol-lowering actions, including
inhibition of platelet activation. Platelet activation is relevant to a variety of coronary heart diseases. Although the inhibitory
effect of simvastatin in platelet activation has been studied; the detailed signal transductions by which simvastatin inhibit
platelet activation has not yet been completely resolved. |
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