Damaged DNA-binding protein 2 (DDB2) protects against UV irradiation in human cells and Drosophila |
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| Authors: | Nian-Kang Sun Chun-Ling Sun Chia-Hua Lin Li-Mai Pai Chuck CK Chao |
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| Affiliation: | (1) Department of Biochemistry and Molecular Biology, Chang Gung University, 333 Gueishan, Taoyuan, Taiwan;(2) Division of Biomedical Sciences, Chang Gung Institute of Technology, 333 Gueishan, Taoyuan, Taiwan |
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| Abstract: | Background We observed previously that cisplatin-resistant HeLa cells were cross-resistant to UV light due to accumulation of DDB2, a protein implicated in DNA repair. More recently, we found that cFLIP, which represents an anti-apoptotic protein whose level is induced by DDB2, was implicated in preventing apoptosis induced by death-receptor signaling. In the present study, we investigated whether DDB2 has a protective role against UV irradiation and whether cFLIP is also involved in this process. |
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