Autonomic neuropathy in Fabry disease: a prospective study using the Autonomic Symptom Profile and cardiovascular autonomic function tests |
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| Authors: | Marieke Biegstraaten Ivo N van Schaik Wouter Wieling Frits A Wijburg Carla EM Hollak |
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| Affiliation: | (1) Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands;(2) Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands;(3) Department of Pediatrics, Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands;(4) Department of Internal Medicine, Division of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, the Netherlands |
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| Abstract: | Background Fabry patients have symptoms and signs compatible with autonomic dysfunction. These symptoms and signs are considered to be due to impairment of the peripheral nervous system, but findings indicative of autonomic neuropathy in other diseases, such as orthostatic intolerance and male sexual dysfunction, are infrequently reported in Fabry disease. The aim of our study was to investigate autonomic symptoms and cardiovascular autonomic function in a large cohort of male and female Fabry patients. |
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