Infections after bone allograft surgery: a prospective study by a hospital bone bank using frozen femoral heads from living donors |
| |
Authors: | Thomas Kappe Balkan Cakir Thomas Mattes Heiko Reichel Markus Flören |
| |
Institution: | (1) University of Ulm, Ulm, Germany; |
| |
Abstract: | In the advent of the EU guidelines 2004/23/EG and 2006/17/EG requiring extensive safety and quality steps in bone banking,
the prevalence and risk of infection disease transmission from bone allograft needs to be reconsidered. Therefore, we prospectively
reviewed the screening process of bone donations and the outcome of surgeries utilizing bone allografts from our internal
hospital bone bank with regard to infections according to CDC criteria. One-hundred and eighty-eight allogenic bone transplantation
procedures in 160 patients were followed-up for 12–64 months (mean 32 months). Bacterial infection occurred in 11 patients,
the overall infection rate therefore was 6.9%. After review of the clinical and intraoperative findings, none of the infections
were likely to have been caused by the bone graft. Although no follow-up serologic testing was performed, no HIV of hepatitis
infections were observed. Frozen bone allografts derived from live donors and provided by hospitals can generally be considered
safe. However, without new and relevant clinical expertise, continuing this technique will be impeded by the new EU guidelines
and their national implementations. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|