Caffeine and a selective adenosine A2A receptor antagonist induce sensitization and cross-sensitization behavior associated with increased striatal dopamine in mice |
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| Authors: | Chih W Hsu Chin S Wang Ted H Chiu |
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| Affiliation: | (1) Department of Emergency Medicine, Tzu Chi General Hospital, Taiwan;(2) Institute of Medical Sciences, Tzu Chi University, 970 Hualien, Taiwan;(3) Institute of Pharmacology and Toxicology, Tzu Chi University, 970 Hualien, Taiwan;(4) School of Medicine, Tzu Chi University, 970 Hualien, Taiwan;(5) Department of Pharmacology, Tzu Chi University, 970 Hualien, Taiwan |
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| Abstract: | Background Caffeine, a nonselective adenosine A1 and A2A receptor antagonist, is the most widely used psychoactive substance in the world. Evidence demonstrates that caffeine and selective adenosine A2A antagonists interact with the neuronal systems involved in drug reinforcement, locomotor sensitization, and therapeutic effect in Parkinson's disease (PD). Evidence also indicates that low doses of caffeine and a selective adenosine A2A antagonist SCH58261 elicit locomotor stimulation whereas high doses of these drugs exert locomotor inhibition. Since these behavioral and therapeutic effects are mediated by the mesolimbic and nigrostriatal dopaminergic pathways which project to the striatum, we hypothesize that low doses of caffeine and SCH58261 may modulate the functions of dopaminergic neurons in the striatum. |
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