The effect of C2-fluoro group on the biological activity of DC-81 and its dimers |
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| Authors: | Kamal Ahmed Reddy P S M M Reddy D Rajasekhar |
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| Affiliation: | Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.ap.nic.in |
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| Abstract: | C2-Fluoro substituted pyrrolobenzodiazepines (PBDs) have been synthesized that exhibit potential anticancer activity in a number of human tumour cell lines. These C2-fluoro substituted PBDs also exhibit significant DNA-binding ability. |
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