Ca(2+) sensors of L-type Ca(2+) channel |
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Authors: | Romanin C Gamsjaeger R Kahr H Schaufler D Carlson O Abernethy D R Soldatov N M |
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Institution: | Institute for Biophysics, University of Linz, Austria. |
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Abstract: | Ca(2+)-induced inactivation of L-type Ca(2+) is differentially mediated by two C-terminal motifs of the alpha(1C) subunit, L (1572-1587) and K (1599-1651) implicated for calmodulin binding. We found that motif L is composed of a highly selective Ca(2+) sensor and an adjacent Ca(2+)-independent tethering site for calmodulin. The Ca(2+) sensor contributes to higher Ca(2+) sensitivity of the motif L complex with calmodulin. Since only combined mutation of both sites removes Ca(2+)-dependent current decay, the two-site modulation by Ca(2+) and calmodulin may underlie Ca(2+)-induced inactivation of the channel. |
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