Genome-wide identification and evolution of ATP-binding cassette transporters in the ciliate <Emphasis Type="Italic">Tetrahymena thermophila</Emphasis>: A case of functional divergence in a multigene family |
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| Authors: | Jie Xiong Lifang Feng Dongxia Yuan Chengjie Fu Wei Miao |
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| Institution: | 1.Key Laboratory of Aquatic Biodiversity and Conservation,Institute of Hydrobiology, Chinese Academy of Sciences,Wuhan,PR China;2.State Key Laboratory of Freshwater Ecology and Biotechnology,Institute of Hydrobiology, Chinese Academy of Sciences,Wuhan,PR China;3.Program in Systematic Biology,Evolutionary Biology Centre,Uppsala,Sweden;4.College of Food Science and Biotechnology,Zhejiang Gongshang University,Hangzhou,PR China;5.Graduate School of Chinese Academy of Sciences,Beijing,PR China |
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| Abstract: | Background In eukaryotes, ABC transporters that utilize the energy of ATP hydrolysis to expel cellular substrates into the environment
are responsible for most of the efflux from cells. Many members of the superfamily of ABC transporters have been linked with
resistance to multiple drugs or toxins. Owing to their medical and toxicological importance, members of the ABC superfamily
have been studied in several model organisms and warrant examination in newly sequenced genomes. |
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