Alterations in acetylcholinesterase isoenzyme pattern of hippocampus after septal lesions in rat brain |
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Authors: | Oderfeld-Nowak B Skangiel-Kramska J |
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Affiliation: | Department of Biochemistry of Nervous System and Muscle, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland. |
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Abstract: | The effect of septal lesions upon the AChE (EC 3.1.1.7) isoenzymic pattern in the hippocampus of the rat brain was studied 1-3 months after surgery by means of polyacrylamide disc electrophoresis. Alterations in the isoenzymic pattern were found in the membrane-bound but not in the soluble fraction of the enzyme. In addition to the two slowly migrating bands seen in the membrane-bound AChE fraction of the normal hippocampus, the fast-migrating isoenzyme becomes visible. |
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