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High Toxoplasma gondii Seropositivity among Brain Tumor Patients in Korea
Authors:Bong-Kwang Jung  Hyemi Song  Min-Jae Kim  Jaeeun Cho  Eun-Hee Shin  Jong-Yil Chai
Affiliation:1Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul 03080, Korea;2Korea Association of Health Promotion, Seoul 07653, Korea;3Seoul National University Bundang Hospital, Seongnam 13620, Korea
Abstract:Toxoplasma gondii is an intracellular protozoan that can modulate the environment of the infected host. An unfavorable environment modulated by T. gondii in the brain includes tumor microenvironment. Literature has suggested that T. gondii infection is associated with development of brain tumors. However, in Korea, epidemiological data regarding this correlation have been scarce. In this study, in order to investigate the relationship between T. gondii infection and brain tumor development, we investigated the seroprevalence of T. gondii among 93 confirmed brain tumor patients (various histological types, including meningioma and astrocytoma) in Korea using ELISA. The results revealed that T. gondii seropositivity among brain tumor patients (18.3%) was significantly (P<0.05) higher compared with that of healthy controls (8.6%). The seropositivity of brain tumor patients showed a significant age-tendency, i.e., higher in younger age group, compared with age-matched healthy controls (P<0.05). In conclusion, this study supports the close relationship between T. gondii infection and incidence of brain tumors.
Keywords:Toxoplasma gondii   seroprevalence   brain tumor   ELISA
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