Host serum malic dehydrogenase activity associated with Trypanosoma lewisi infection |
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| Authors: | D R Lincicome M R McLean |
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| Affiliation: | Department of Zoology, Howard University, Washington, D.C. 20001 USA;National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014 USA |
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| Abstract: | A significant reduction in host serum malic dehydrogenase was demonstrated in Trypanosoma lewisi-infected rats. This prevailed during the active (reproductive) state of parasitemia, after which the serum MDH activity resumed normal levels.In vitro incubation studies involving trypanosome extracts and immune or normal rat sera indicated that the reduction was not a direct effect but of a more complex nature. |
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