Lys3]Didemnins as potential affinity ligands |
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| Authors: | Vera M D Pfizenmayer A J Ding X Xiao D Joullié M M |
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| Affiliation: | Department of Chemistry, University of Pennsylvania, Philadelphia 19104-6323, USA. |
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| Abstract: | The synthesis and biological activity of N(epsilon)-Z-[Lys3]didemnin B are reported. This novel analogue retains antiproliferative, cytotoxic, and protein biosynthesis inhibition activities, but at reduced levels. This result suggests the use of [Lys3]didemnin derivatives as potential affinity probes for studying the molecular target(s) of the didemnin class of natural products. |
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