Immunoglobulin properties of Epstein-Barr virus transformed human umbilical cord and adult peripheral blood lymphocytes |
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| Authors: | J Konowalchuk J I Speirs L Perelmutter |
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| Affiliation: | Division of Rheumatology and Immunobiology Laboratories, Departments of Medicine and Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 USA |
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| Abstract: | We have observed that a subset of E+ cells bind human monomeric IgG (FcR-IgG). In the present study, we have separated the E+, FcR-IgG+ cells by flow cytometry and tested their NK activity against the tumor KS62 using the chromium-release assay. Virtually all the NK activity residing within the E+ subset was mediated by E+, FcR-IgG+ cells. These findings are discussed in relation to the cellular lineage of the human NK cell. |
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| Keywords: | To whom reprint requests should be addressed. |
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