细胞药物的种类及生物学特性——细胞药物连载之一

细胞药物是以不同细胞为基础的用于疾病治疗的制剂、药物或产品的统称,是继放疗、化疗之后又一种临床有效的治疗手段,可实施个性化治疗。细胞药物的种类很多,按其生物学特性可分为传统体细胞、免疫细胞以及各种不同的干细胞等。经体外操作过的细胞群,如肝细胞、胰岛细胞、软骨细胞、树突状细胞、细胞因子诱导的杀伤细胞、淋巴因子激活的杀伤细胞、体外加工的骨髓或造血干细胞和体外处理的肿瘤细胞(瘤苗)等。细胞药物已在一些难治性疾病中得到应用,包括血液系统疾病、心血管系统疾病、消化系统疾病、神经系统疾病、免疫系统疾病和抗衰老等。细胞治疗涉及的细胞种类很多,且不同细胞或不同治疗方法各有特点。运用不同的细胞药物来修复病变细胞,以重建受损的功能细胞和组织,恢复其生物学功能,为细胞丢失或损伤性疾病的防治提供了崭新的思路。

The Types and Biological Characteristics of Cell Drug

Cell drug includes the agent, medicine or product that can be based on different cells to treat disease, which is an effective clinical therapeutical method after radiotherapy and chemotherapy and may be implemented individualized treatment. There are many types of cells drugs which are divided into the traditional somatic cells, immune cells and different types of stem cells, etc., according to their biological characteristics. The cells were operated outside the body including liver cells, islet cells, cartilage cells, dendritic cells, cytokine induced killer cells, lymphatic factor activated killer cells, processed bone marrow or blood stem cells in vitro, and treated tumor cells (tumor vaccines) in vitro, etc. Cell drug has already been used in some refractory diseases, including blood system diseases, cardiovascular system diseases, digestive system diseases, nervous system diseases, immune system diseases, and anti-aging. Cell therapy is involved in many cell types, and different cells or different treatment methods have different characteristics. Different cell drugs are used to repair the diseased cells for rebuilding the damaged function cells and tissues and restoring their biological function, which provides a new train of thought for the prevention and control of cell loss or traumatic disease.