|
|||||
|
|
Effect of running training on uncoupling protein mRNA expression in rat brown adipose tissue |
|
| Authors: | Hitoshi Yamashita Mikio Yamamoto Yuzo Sato Tetsuya Izawa Takao Komabayashi Daizo Saito Hideki Ohno |
| Institution: | (1) Departments of Hygiene, National Defense Medical College, 3-2 Namiki, 359 Tokorozawa, Japan;(2) Departments of Biochemistry II, National Defense Medical College, 3-2 Namiki, 359 Tokorozawa, Japan;(3) Research Center of Health, Physical Fitness and Sports, Nagoya University, 464 Nagoya, Japan;(4) Laboratory for Exercise and Applied Physiology, Tokyo College of Pharmacy, 192-03 Hachioji, Japan;(5) Department of Physiology and Pharmacology, Tokyo College of Pharmacy, 192-03 Hachioji, Japan;(6) Departments of Emergency, National Defense Medical College, 3-2 Namiki, 359 Tokorozawa, Japan |
| Abstract: | The effect was investigated of endurance training on the expression of uncoupling protein (UCP) mRNA in brown adipose tissue (BAT) of rats. The exercised rats were trained on a rodent treadmill for 5 days per week and a total of 9 weeks. After the training programme, a marked decrease in BAT mass was found in terms of weight or weight per unit body weight; there was a corresponding decrease in DNA content and a downward trend in RNA and glycogen levels. The UCP mRNA was present at a markedly decreased level in BAT of trained animals. In consideration of the reduced levels of mRNAs for hormone-sensitive lipase and acylCoA synthetase, the brown adipose tissue investigated appeared to be in a relatively atrophied and thermogenically quiescent state. |
| Keywords: | Running training Uncoupling protein mRNA Rat brown adipose tissue |
| 本文献已被 SpringerLink 等数据库收录！ | |