H3K27 demethylases, at long last |
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Authors: | Swigut Tomek Wysocka Joanna |
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Institution: | Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. |
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Abstract: | Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation of genes involved in animal body patterning and the inflammatory response. |
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