Foetal plasma steroid concentrations related to gestational age and method of delivery. |
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| Authors: | I D Smith D A Shutt R P Shearman |
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| Affiliation: | 1. FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Finland;2. Department of Child Psychiatry, University of Turku and Turku University Hospital, Turku, Finland;3. Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland;4. Institute of Biomedicine, University of Turku, Finland;5. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;1. University of Salzburg, Department of Psychology, Division of Social Psychology, Hellbrunnerstraße 34, 5020 Salzburg, Austria;2. University of Salzburg, Department of Psychology, Hellbrunnerstraße 34, 5020 Salzburg, Austria;3. University of Salzburg, Centre for Cognitive Neuroscience, Ignaz-Harrer-Straße 79, 5020 Salzburg, Austria;4. University of Salzburg, Department of Psychology, Division of Clinical Psychology, Psychotherapy, and Health Psychology, Hellbrunnerstraße 34, 5020 Salzburg, Austria;1. Department of Pediatrics, University of Calgary, 2500 University Drive N.W., Calgary, AB T2N 1N4, Canada;2. Department of Community Health Sciences, University of Calgary, 2500 University Drive N.W., Calgary, AB T2N 1N4, Canada;3. Alberta Children’s Hospital Research Institute, University of Calgary, 2500 University Drive N.W., Calgary, AB T2N 1N4, Canada;4. Department of Psychology, University of Calgary, 2500 University Drive N.W., Calgary, AB T2N 1N4, Canada;5. Allan Centre for Women & Department of Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada;6. Comparative Biology & Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive N.W., Calgary, AB T2N 4N1, Canada;7. Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive N.W., Calgary, AB T2N 4N1, Canada |
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| Abstract: | Levels of total corticosteroids and unconjugated oestrone and oestradiol-17β in human umbilical arterial and venous plasma at the time of delivery were measured, using competitive protein-binding methods. Increased corticosteroid levels were associated with the establishment of labour and, following delivery at term (38–40 weeks), corticosteroid levels were least when the mother was not in labour and greatest when the mother was in established spontaneous labour at the time of delivery. A surge and peak in corticosteroid levels was observed at 35–37 weeks of gestation in infants delivered by elective Caesarean section and per vaginam following spontaneous labour and thus was not related to labour.Oestrone and oestradiol-17β levels in umbilical venous plasma have also been shown to change with the establishment of labour, oestrone levels increasing and oestradiol-17β levels falling, so that oestrone predominates. Following spontaneous labour with vaginal delivery, there was a significant effect of parity upon oestrogen levels, higher levels of both oestrone and oestradiol-17β occurring in infants from primiparous mothers. This effect of parity was not observed following Caesarean section, either when in early labour or not in labour. It is concluded that fluctuations in corticosteroid and oestrogen levels in the feto-placental circulation are associated with the establishment of labour and may therefore have a regulatory role in human parturition. |
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