| c-Abl在DNA损伤反应中的功能 |
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| 引用本文： | 李伟,曹诚. c-Abl在DNA损伤反应中的功能[J]. 生物技术通讯, 2014, 0(1): 122-124,130 |
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| 作者姓名： | 李伟 曹诚 |
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| 作者单位： | [1]军事医学科学院生物工程研究所,北京100850 [2]第二炮兵总医院中心实验室,北京100088 |
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| 摘 要： | 非受体酪氨酸激酶c-Abl在正常生理及病理条件下具有多种生物学功能。当电离辐射、顺铂、丝裂霉素C等DNA损伤诱导剂诱导DNA损伤反应后,c-Abl可参与DNA损伤反应后的细胞周期调控、基因重组修复及细胞凋亡调控等,进而决定细胞在DNA损伤反应条件下的状态。简要介绍了c-Abl在DNA损伤反应中的作用及其进展。
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| 关 键 词： | c-Abl 激酶 DNA损伤反应 |
Roles of c-Abl in DNA Damage Response |
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| LI Wei^,CAO Cheng. Roles of c-Abl in DNA Damage Response[J]. Letters in Biotechnology, 2014, 0(1): 122-124,130 |
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| Authors: | LI Wei^ CAO Cheng |
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| Affiliation: | 1＊ 1. Beijing Institute of Bioteehnology, Beijing 100850; 2. Central Laboratory, General Hospital of the Second Artil- lery, Beijing 100088; China ＊Corresponding author, E-mail： eao@nic.bmi.ae.en |
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| Abstract: | Non-receptor tyrosine kinase c-Abl has been implicated diverse roles in normal physiological and pathological condition. When DNA was damaged by ionizing radiation, cisplatin, mytomycin C, c-Abl can regulate cell cycle, gene recombination repair and cell apoptosis, which would decide cell condition in DNA damage re sponse. The progress of roles of c-Abl was introduced in this review. |
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| Keywords: | c-Abl kinase DNA damage response |
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