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Mutations affecting retina development in Medaka |
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| Authors: | Loosli Felix Del Bene Filippo Quiring Rebecca Rembold Martina Martinez-Morales Juan-Ramon Carl Matthias Grabher Clemens Iquel Caroline Krone Annette Wittbrodt Beate Winkler Sylke Sasado Takao Morinaga Chikako Suwa Hiroshi Niwa Katsutoshi Henrich Thorsten Deguchi Tomonori Hirose Yukihiro Iwanami Norimasa Kunimatsu Sanae Osakada Masakazu Watanabe Tomomi Yasuoka Akihito Yoda Hiroki Winkler Christoph Elmasri Harun Kondoh Hisato Furutani-Seiki Makoto Wittbrodt Joachim |
| Affiliation: | European Molecular Biology Laboratory, Developmental Biology Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany. |
| Abstract: | In a large scale mutagenesis screen of Medaka we identified 60 recessive zygotic mutations that affect retina development. Based on the onset and type of phenotypic abnormalities, the mutants were grouped into five categories: the first includes 11 mutants that are affected in neural plate and optic vesicle formation. The second group comprises 15 mutants that are impaired in optic vesicle growth. The third group includes 18 mutants that are affected in optic cup development. The fourth group contains 13 mutants with defects in retinal differentiation. 12 of these have smaller eyes, whereas one mutation results in enlarged eyes. The fifth group consists of three mutants with defects in retinal pigmentation. The collection of mutants will be used to address the molecular genetic mechanisms underlying vertebrate eye formation. |
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