The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein |
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Authors: | Barouki Robert Coumoul Xavier Fernandez-Salguero Pedro M |
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Affiliation: | INSERM, UMR-S 747, 75270 Paris Cedex 06, France. robert.barouki@univ-paris5.fr |
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Abstract: | The aryl hydrocarbon (dioxin) receptor (AhR) has been studied for several decades largely because of its critical role in xenobiotic-induced toxicity and carcinogenesis. Albeit this is a major issue in basic and clinical research, an increasing number of investigators are turning their efforts to try to understand the physiology of the AhR under normal cellular conditions. This is an exciting area that covers cell proliferation and differentiation, endogenous mechanisms of activation, gene regulation, tumor development and cell motility and migration, among others. In this review, we will attempt to summarize the studies supporting the implication of the AhR in those endogenous cellular processes. |
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Keywords: | AhR, aryl hydrocarbon (dioxin) receptor ARNT, aryl hydrocarbon nuclear translocator JNK, c-Jun N-terminal kinase TGFβ, transforming growth factor β |
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