First direct discrimination of chiral phosphorus thionate (P=S) derivatives by multinuclear magnetic resonance spectroscopy in the presence of a chiral dirhodium complex |
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| Authors: | Rockitt S Duddeck H Omelanczuk J |
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| Affiliation: | Hannover University, Institute of Organic Chemistry, Hannover, Germany. |
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| Abstract: | Enantiomeric ratios of compounds with P=S functionalities can be determined by 1H, 13C, and 31P NMR spectroscopic inspection of their diastereomeric complexes with (R)-Rh2(MTPA)4 (MTPA-H identical with methoxytrifluoromethylphenylacetic acid; Mosher's acid). This is the first facile and rapid spectroscopic method for chiral recognition in this class of compounds. Whereas complexation shifts Deltadelta are moderate or even negligible, significant signal dispersions Delta(nu) can be observed. Some rationalization about the complexation mode is presented. The NMR spectral characteristics of the free P=S compounds 1-9 are described in detail. |
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| Keywords: | phosphino thionates phosphono thionates chiral recognition diastereomeric dirhodium complexes 1H, 13C, 31P NMR heteronuclear coupling constants |
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