Migration inhibitory factor (MIF) production by skin fibroblast cultures from patients with severe combined immunodeficiency |
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| Authors: | P S Papageorgiou P R Glade |
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| Affiliation: | Department of Pediatrics, Division of Infectious Diseases, The Mount Sinai School of Medicine of the City University of New York, New York 10029 U.S.A. |
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| Abstract: | The supernatants of fibroblast cultures derived from skin biopsies of each of two patients with severe combined immunodeficiency were studied for the presence of migration inhibitory activity (MIF). The supernatants of both of these fibroblast cultures were found to contain inhibitory activity for the migration of cultured human lymphoid cells (PGLC-33H). This MIF activity was found to share chromatographic similarities with the MIF contained in the supernatants of a lymphoid cell line (PGLC-33H) and phytohemagglutinin (PHA) and tuberculin (PPD) stimulated human peripheral lymphocytes. These data suggest that MIF is not solely a lymphoid product and that severe combined immunodeficiency does not represent a gene deletion for MIF production. |
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