Cell and tissue cultures of Catharanthus roseus: A literature survey |
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| Authors: | Paulo R. H. Moreno Robert van der Heijden Robert Verpoorte |
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| Affiliation: | (1) Division of Pharmacognosy, Gorlaeus Laboratories, Leiden/Amsterdam Center for Drug Research, P.O. Box 9502, 2300 RA Leiden, The Netherlands |
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| Abstract: | The literature concerning the regulation and the biosynthesis of secondary metabolites in cell and tissue cultures of Catharanthus roseus is reviewed. The aim of this review is to summarise the progress achieved since the previous review of this subject from 1988 to December 1993. Several factors influencing the production of indole alkaloids are discussed. Special attention is given to large-scale cultivation methods. Some economic considerations on the production of ajmalicine are also discussed. |
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| Keywords: | Biosynthesis Catharanthus roseus cell culture indole alkaloids large-scale production review tissue culture |
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