Anti-oestrogen Therapy for Breast Cancer: A Trial of Tamoxifen at Two Dose Levels |
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Authors: | H. W. C. Ward |
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Abstract: | Tamoxifen (ICI 46474) was given by mouth to patients with advanced, recurrent, or metastatic breast carcinoma. At a dosage of 10 mg twice daily 60% of patients showed arrest or reversal of tumour growth. At a dosage of 20 mg twice daily 77% showed arrest or reversal of tumour growth. Side effects were usually trivial and their incidence was the same at both dose levels. No patients showed virilization of fluid retention. |
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