Effect of Orally Administered Prostaglandin E2 and its 15-Methyl Analogues on Gastric Secretion

The effect of orally administered prostaglandin E₂ and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E₂ compound did not inhibit basal secretion, whereas both the 15 (S) 15-methyl-E₂ methyl ester and its isomer, 15 (R) 15-methyl-E₂ methyl ester inhibited basal acid secretion. This action is likely to be a direct one on the parietal cell, and it could prove of value in the treatment of peptic ulcer.