Activity of oxyntomodulin on gastric acid secretion induced by histamine or a meal in the rat |
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Authors: | Claire Jarrousse Chantal Carles-Bonnet Huguette Niel and Dominique Bataille |
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Institution: | Centre CNRS-INSERM de Pharmacologie Endocrinologie U376, rue de la Cardonille, 34094, Montpellier Cedex 05, France |
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Abstract: | Conscious rats with chronic gastric fistula were trained for drinking a 14-ml milk meal. The activity of an intestinal hormone, oxyntomodulin (OXM), was studied in this model and compared to that observed when histamine was the stimulus. Under histamine (0.25 mg·kg−1·h−1) stimulation, OXM at doses (60–120 pmol·kg−1·h−1) that induced physiological circulating levels inhibited gastric acid secretion up to 50%. Under meal stimulation, OXM reduced up to 29% acid secretion at doses (1–1.5 nmol·kg−1·h−1) inducing supraphysiological levels. We conclude that at physiological concentrations OXM cannot counteract the complex processes triggered by a meal. OXM would be a component of enterogastrone, a combination of several intestinal hormones acting in synergy. The OXM action is related to pathways recognizing the C-terminal 19–37 moiety of the molecule. |
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Keywords: | Gastric acid secretion Oxyntomodulin 19–37 fragment Milk Liquid meal Histamine Rat |
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