Sortilin and SorLA Regulate Neuronal Sorting of Trophic and Dementia-Linked Proteins |
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Authors: | Lone Tjener Pallesen Christian Bjerggaard Vaegter |
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Institution: | 1.The Lundbeck Foundation Research Centre MIND, Department of Biomedicine,Aarhus University,Aarhus C,Denmark |
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Abstract: | Sortilin and SorLA are members of the Vps10p domain receptor family, the Sortilins, which comprise five type I transmembrane
receptors differentially expressed in neuronal tissues of the central and peripheral nervous system. Since the identification
of sortilin in 1997, members of this receptor family are recognized as sorting receptors primarily in the trans-Golgi network,
interacting with a wide range of ligands comprising other transmembrane receptors as well as soluble proteins from neurotrophic
factors to enzymes targeted for lysosomes. Specifically, the involvement of sortilin in neutrophin signaling in healthy and
injured neurons is increasingly recognized, as well as the impact of SorLA on the cellular processing of amyloid precursor
protein, an important component in Alzheimer’s disease. The current understanding of these issues as well as the recent recognition
of a molecular link between sortilin and frontotemporal dementia is addressed in this present review. |
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