| 14-3-3蛋白在细胞周期调节中的作用 |
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| 引用本文： | 苑存忠,杨蕾蕾,滕艳,杨晓. 14-3-3蛋白在细胞周期调节中的作用[J]. 生物技术通讯, 2007, 18(5): 815-819 |
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| 作者姓名： | 苑存忠 杨蕾蕾 滕艳 杨晓 |
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| 作者单位： | 军事医学科学院,生物工程研究所,北京,100071 |
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| 摘 要： | 14-3-3是一个在真核细胞中广泛表达、功能复杂的蛋白家族，主要通过磷酸化依赖的方式与靶蛋白结合，从而发挥其调控作用。细胞周期的调节对维持基因组的稳定性至关重要。近年来的研究发现，14-3—3蛋白可以和越来越多的细胞周期调节蛋白相互作用，调节G2／M期和G1／S期转换，从而对细胞周期起调控作用。简要综述了14—3—3蛋白在细胞周期调节中的作用。
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| 关 键 词： | 14-3-3蛋白 细胞周期 调节 激酶 磷酸化 |
| 文章编号： | 1009-0002（2007）06-0815-05 |
| 修稿时间： | 2007-03-23 |
Roles of 14-3-3 Proteins in Cell Cycle Regulation |
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| YUAN Cun-zhong,YANG Lei-lei,TENG Yan,YANG Xiao. Roles of 14-3-3 Proteins in Cell Cycle Regulation[J]. Letters in Biotechnology, 2007, 18(5): 815-819 |
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| Authors: | YUAN Cun-zhong YANG Lei-lei TENG Yan YANG Xiao |
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| Affiliation: | Beijing Institute of Biotechnology, Beijing 100071, China |
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| Abstract: | 14-3-3, a proteins family that expresses in eukaryotic cell extensively and regulates many cellular processes by interaction with target proteins in a phosphorylation-dependent manner. Cell cycle regulation is essential for the maintenance of genomic integrity. It was revealed recently that 14-3-3 can associate more and more cell cycle regulator, thus regulate G2/M and G1/S transtion in cell cycle. Roles of 14-3-3 proteins in cell cycle regulation were reviewed in this paper. |
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| Keywords: | 14-3-3 proteins cell cycle regulation kinase phosphorylation |
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