| 神经酰胺与细胞凋亡 |
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| 引用本文： | 金朝晖,李薇,潘华珍. 神经酰胺与细胞凋亡[J]. 生物化学与生物物理进展, 1999, 26(6): 537-541 |
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| 作者姓名： | 金朝晖 李薇 潘华珍 |
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| 作者单位： | 上海市第六人民医院血液科，上海 200233;上海市闵行区中心医院肿瘤科，上海 201100;中国医学科学院中国协和医科大学基础医学研究所，北京 100005 |
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| 摘 要： | 细胞凋亡 (apoptosis) 又称细胞的程序性死亡，参与机体许多生理和病理过程.近年来的研究表明细胞凋亡与鞘脂质代谢有密切的关系，鞘磷脂的水解产物神经酰胺作为脂质第二信使在诱导和抑制细胞凋亡中起着重要的作用.
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| 关 键 词： | 细胞凋亡 鞘脂质 神经酰胺 |
| 收稿时间： | 1998-10-13 |
| 修稿时间： | 1999-03-08 |
Ceramide and Apoptosis |
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| JIN Zhao-Hui,LI Wei and PAN Hua-Zhen. Ceramide and Apoptosis[J]. Progress In Biochemistry and Biophysics, 1999, 26(6): 537-541 |
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| Authors: | JIN Zhao-Hui LI Wei PAN Hua-Zhen |
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| Affiliation: | Department of Hematology, Shanghai Sixth Hospital, Shanghai 200233, China;Department of Oncology, Shanghai Minhang District Hospital, Shanghai 201101, China;National Laboratory of Medical Molecular Biology, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100005, China |
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| Abstract: | Apoptosis is a highly organized mechanism by which cells undergo programed cell death. Apoptosis participates in many physiological and pathological processes. Recent experimental approaches suggest that sphingolipid metabolites participate in key events of apoptosis. Being a lipid second messenger, sphingomyelin lysis product-ceramide play an important role in inducing and preventing apoptosis. |
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| Keywords: | apoptosis sphingolipid ceramide |
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