In vivo modification of porin activity conferring antibiotic resistance to Enterobacter aerogenes |
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Authors: | Chevalier J Pagès J M Malléa M |
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Affiliation: | CJF 9606 INSERM, Université de la Méditerannée, Marseille Cedex 05, 13385, France. |
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Abstract: | Cephalosporins are widely used in chemotherapy of bacterial infections and resistance mechanisms seriously impair their antibacterial activity. Several resistant strains of Enterobacter aerogenes, a frequently isolated nosocomial pathogen, were analyzed. One isolate exhibited a strong modification of the porin antigenic pattern, especially with an immunological probe directed against an epitope located inside the pore lumen. A strong decrease of cefepime uptake was evidenced for this isolate, similarly to ones observed for porin-deficient strains: these kinetics show a serious alteration of the channel properties which may support cephalosporin resistance. This is the first E. aerogenes isolate using such adaptive response which defines an original enterobacterial answer to cephalosporin. |
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