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Phosphorylation of mitochondrial membrane proteins: effect of the surface potential on monoamine oxidase |
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| Authors: | Kazuhiko Tatemoto Åke Rökaeus Hans Jörnvall Thomas J. McDonald Viktor Mutt |
| Affiliation: | 1. Department of Biochemistry II, Karolinska Institute, S-104 01 Stockholm, Sweden;2. Department of Pharmacology, Karolinska Institute, S-104 01 Stockholm, Sweden;3. Department of Chemistry I, Karolinska Institute, S-104 01 Stockholm, Sweden;4. Department of Medicine, University of Western Ontario, London, Canada |
| Abstract: | The isolation of a novel biologically active peptide, designated galanin, is described. The peptide was discovered by the detection of its C-terminal amide structure in porcine intestinal extract using a chemical method. It was found that galanin consists of 29 amino acids and the complete amino acid sequence is: Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His -Arg-Ser -Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2. Galanin was found to contract smooth muscle preparations from the rat and to cause a mild and sustained hyperglycemia in dog. |
| Keywords: | Gastrointestinal polypeptide Amino acid sequence C-terminal amide Biologicl activity |
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