Genome-wide survey of post-meiotic segregation during yeast recombination |
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| Authors: | Eugenio Mancera Richard Bourgon Wolfgang Huber Lars M Steinmetz |
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| Institution: | (1) European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany;(2) European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, CB10 1SD, UK;(3) Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA |
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| Abstract: | Background When mismatches in heteroduplex DNA formed during meiotic recombination are left unrepaired, post-meiotic segregation of the
two mismatched alleles occurs during the ensuing round of mitosis. This gives rise to somatic mosaicism in multicellular organisms
and leads to unexpected allelic combinations among progeny. Despite its implications for inheritance, post-meiotic segregation
has been studied at only a few loci. |
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