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Early atherosclerosis in systemic sclerosis and its relation to disease or traditional risk factors |
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| Authors: | Martha E Hettema Dan Zhang Karina de Leeuw Ymkje Stienstra Andries J Smit Cees GM Kallenberg Hendrika Bootsma |
| Affiliation: | (1) Department of Internal Medicine, Division of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30.001, 9700, RB, Groningen, The Netherlands;(2) Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30.001, 9700, RB, Groningen, The Netherlands;(3) Department of Internal Medicine, Division of Vascular Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30.001, 9700, RB, Groningen, The Netherlands |
| Abstract: | IntroductionSeveral systemic autoimmune diseases are associated with an increased prevalence of atherosclerosis which could not be explained by traditional risk factors alone. In systemic sclerosis (SSc), microvascular abnormalities are well recognized. Previous studies have suggested an increased prevalence of macrovascular disease as well. We compared patients with SSc to healthy controls for signs of early atherosclerosis by measuring intima-media thickness (IMT) of the common carotid artery in relation to traditional risk factors and markers of endothelial activation. |
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