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Novel antiglaucoma prodrugs and codrugs of ethacrynic acid |
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| Authors: | Cynkowska Grazyna Cynkowski Tadeusz Al-Ghananeem Abeer M Al-Ghananeem Abeer A Guo Hong Ashton Paul Crooks Peter A |
| Institution: | New England Eye Center, Boston, MA 02111, USA. |
| Abstract: | The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the beta-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties. |
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