Genetic control of the cell division cycle in yeast : II. Genes controlling DNA replication and its initiation |
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| Authors: | Leland H Hartwell |
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| Institution: | Department of Genetics University of Washington, Seattle, Wash. 98105, U.S.A. |
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| Abstract: | Temperature-sensitive mutations occurring in two unlinked complementation groups, cdc4 and cdc8, are recessive and result in a defect in DNA replication at the restrictive temperature. Results obtained with synchronous cultures suggest that cdc4 functions in the initiation of DNA replication and cdc8 functions in the propagation of DNA replication. |
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