Development of serotonergic neurons of dorsal raphe nuclei in mice with knockout of monoamine oxidase a and 5-HT1A and 5-HT1B autoreceptor |
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Authors: | N. A. Urtikova A. Ya. Sapronova M. -J. Brisorgueil D. Verge M. V. Ugryumov |
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Affiliation: | (1) Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119991, Russia;(2) Neurobiologie des Signaux Intercellulaires (UMR 7101 IFR 83 CNRS UPMC), Universite Pierre et Marie Curie, 7 Quai Saint Bernard, 75252 Paris Cedex 05, France |
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Abstract: | The morphological changes in the development of serotonergic neurons of the dorsal raphe nuclei in the medulla oblongata was studied by immunocytochemistry in mice with knockout of 1A and 1B serotonin autoreceptors as well as monoamine oxidase A. Serotonin autoreceptors regulate electric activity of serotonergic neurons as well as the synthesis and release of the neurotransmitter, while monoamine oxidase A catalyzes its degradation. These genetic modifications proved to have no effect on the number of serotonergic neurons in the medulla oblongata but induced morphofunctional changes. Decreased cell size and increased intracellular serotonin level were observed in the case of monoamine oxidase A deficiency, while excessive cell size and decreased intracellular serotonin level were observed in the case of autoreceptor deficiency. The data obtained confirm the hypothesis of autoregulation of serotonergic neurons in development. |
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Keywords: | serotonin knockout medulla oblongata immunocytochemistry image analysis |
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