| 固体脂质纳米粒的制备及在治疗中的应用研究 |
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| 引用本文： | 殷润婷 杨阳 张婕 葛雪梅 张伟. 固体脂质纳米粒的制备及在治疗中的应用研究[J]. 现代生物医学进展, 2014, 14(36): 7182-7185 |
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| 作者姓名： | 殷润婷 杨阳 张婕 葛雪梅 张伟 |
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| 作者单位： | 南通大学药学院;西北农林科技大学生命学院 |
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| 基金项目： | 江苏省自然科学青年基金项目(81402189);国家自然科学基金项目(81070197);江苏省高校优势学科发展项目 |
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| 摘 要： | 固体脂质纳米粒(SLN)是20世纪90年代发展起来的一种性能优异的新型纳米粒给药剂型作为一种新型载体,可有效提高包封药物的稳定性、提高病变部位靶向性、低毒性与组织亲和性,为药物的体内递送提供了一种新的方法。本文主要针对固体脂质纳米粒的制备,发展现状,目前存在的问题及解决思路等作以介绍与总结。并在此基础上,介绍了新的脂质纳米粒,纳米脂质载体(nanostructured lipid carriers,NLC)和药脂结合物纳米粒(Lipid drug conjugate nanoparticles,LDC),以及未来固体脂质纳米粒的发展方向。
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| 关 键 词： | 固体脂质纳米粒 特点 应用 纳米结构脂质载体 |
The Preparation of Solid Lipid Nanoparticles and Its Application inTherapeuticals |
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| YIN Run-ting,YANG Yang,ZHANG Jie,GE Xue-mei,ZHANG Wei. The Preparation of Solid Lipid Nanoparticles and Its Application inTherapeuticals[J]. Progress in Modern Biomedicine, 2014, 14(36): 7182-7185 |
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| Authors: | YIN Run-ting YANG Yang ZHANG Jie GE Xue-mei ZHANG Wei |
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| Affiliation: | YIN Run-ting;YANG Yang;ZHANG Jie;GE Xue-mei;ZHANG Wei;School of Pharmacy, Nantong University;Northwest A&F University; |
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| Abstract: | Solid lipid nanoparticles (SLN) is an excellent new nanoparticles drug delivery systemwhich developed rapidly since1990s. As a new vector, solid lipid nanoparticles may improve the stability of the encapsulated drugs, enhance targeting efficiency to thediseased site, low toxicity and biocompatibility. It has provided a promising method for drug delivery. This paper reviewed thepreparation, development, the problems and solution in its application of the SLN nano-carriers. Based on previous study, nanostructuredlipid carriers (NLC) and lipid drug conjugated nanoparticles (LDC) and the development of the solid lipid nanoparticles were alsointroduced in this artcle. |
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| Keywords: | SLN Characteristics Application NLC |
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